Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells.
نویسندگان
چکیده
Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.
منابع مشابه
T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system.
Clearance of the neurotropic JHM strain of mouse hepatitis virus from the central nervous system was examined by the transfer of spleen cells from immunized donors. A T cell with the surface phenotype of Thy1.2+ CD4+ CD8- asialo-GM1+ Mac-1- was found to be necessary for viral clearance. The surface phenotype and adherence to nylon wool suggest that these cells are activated helper-inducer T cel...
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CTL responses induced during most viral infections are independent of help derived from the CD4+ T cell population. However, clearance of virus from the central nervous system (CNS) during infection with the neurotropic JHM strain of mouse hepatitis virus is inhibited in the absence of CD4+ T cells. Adoptive transfer of activated CD8+ T cells with virus-specific cytolytic activity into CD4+ T c...
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Replication of the neurotropic mouse hepatitis virus strain JHM (JHMV) is controlled primarily by CD8(+) T-cell effectors utilizing gamma interferon (IFN-gamma) and perforin-mediated cytotoxicity. CD4(+) T cells provide an auxiliary function(s) for CD8(+) T-cell survival; however, their direct contribution to control of virus replication and pathology is unclear. To examine a direct role of CD4...
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The antiviral role of CD4(+) T cells in virus-induced pathologies of the central nervous system (CNS) has not been explored extensively. Control of neurotropic mouse hepatitis virus (JHMV) requires the collaboration of CD4(+) and CD8(+) T cells, with CD8(+) T cells providing direct perforin and gamma interferon (IFN-gamma)-mediated antiviral activity. To distinguish bystander from direct antivi...
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عنوان ژورنال:
- Journal of virology
دوره 64 9 شماره
صفحات -
تاریخ انتشار 1990